Circular Genomics, collaborating with Washington University, discovered a circular RNA-based signature, including circHOMER1, associated with Alzheimer’s disease onset and progression. This biomarker correlates with clinical dementia ratings and neuropathology, offering potential for diagnosis and prognosis. Ongoing research aims to determine specificity beyond Alzheimer’s to broader neurodegeneration, potentially expanding biomarker applications to diseases such as Parkinson’s and dementia with Lewy bodies.