Circadian immunologist Christoph Scheiermann detailed how night shift work causes a misalignment between biological clocks and environmental cues, increasing risks for cardiometabolic, autoimmune disorders, some cancers, and accelerated aging. Epidemiological and molecular studies have established that irregular work hours disrupt physiological functions controlled by circadian rhythms. These insights underscore workplace health challenges facing night shift laborers and drive efforts to mitigate adverse outcomes.