A team led by Wang et al. published a chemical reprogramming method in Cell Research that converts human T cells into pluripotent stem cells without introducing exogenous genetic factors. The protocol uses a defined small‑molecule cocktail to rewrite cell identity, offering an alternative to genetic reprogramming approaches. The result could lower safety barriers tied to integrating vectors and broaden access to patient‑derived pluripotent lines for regenerative medicine and engineered cell products. The method still requires translation and validation for large‑scale manufacture and therapeutic use, but it opens a non‑genetic route to pluripotency in immune cells.