An international team introduced a pan‑cancer detection method that pairs cell‑free DNA (cfDNA) fragment coverage with chromatin accessibility patterns to identify cancer across tumor types and datasets. The approach leverages the relationship between cfDNA fragmentation and the nucleosome landscape to improve signal specificity for tumor‑derived DNA. Authors demonstrate cross‑dataset robustness and argue the technique reduces tumor‑type bias that limits many cfDNA assays. The method could expand noninvasive early‑detection capabilities, though prospective clinical validation and assessment of false‑positive rates will determine its translational path.