Biohub moved to scale “virtual cell” tooling with a major $500 million commitment to build AI-based predictive cell models, aiming to generate multimodal datasets and open access resources. The initiative, called the Virtual Biology Initiative, is supported by the Chan Zuckerberg Initiative and backed by partners including the Allen Institute, Arc Institute, Broad Institute, and Wellcome Sanger Institute, with Nvidia providing technology partnership. In parallel, gene engineering platform work described large-genomic-insert techniques via prime assembly and broader non-viral large DNA integration concepts, addressing a key limitation in gene therapy: efficiently inserting large DNA payloads into cells. For the biotech sector, the combination of large-scale predictive modeling and improved insertion/editing methods points toward faster iteration cycles from target biology to construct design—reducing the time between hypothesis and experimental validation.