PacBio’s leadership shifted after CEO Christian Henry resigned and COO Mark Van Oene was appointed to lead the company. Henry, who took the top role in 2020, oversaw PacBio’s acquisition of short-read sequencing technology firm Omniome—an expansion that has since weighed on the business. The change puts Van Oene in charge as PacBio navigates sequencing technology positioning and product execution while investors and customers assess continuity across the company’s instrument, reagents, and services strategy.