The US Centers for Disease Control and Prevention’s Advisory Committee on Immunization Practices (ACIP) has encountered significant upheaval following the overhaul of members by Health and Human Services Secretary Robert F. Kennedy Jr., a noted vaccine skeptic. The remade panel voted to change longstanding vaccine recommendations, including the removal of the combined MMRV vaccine for children under age 4 and postponing votes on delaying the hepatitis B birth dose. Former CDC director Susan Monarez and chief medical officer Debra Houry testified before the Senate, highlighting political interference undermining scientific rigor and warning of public health risks from weakening vaccine schedules. The American Academy of Pediatrics and other professional groups notably withdrew from the committee in protest. The situation raises concerns about potential resurgence of preventable diseases and erosion of public trust.