Scientists at the Centre for Cellular and Molecular Biology (CCMB) reported that metabolic programs in fungi underpin invasive behavior and determine responsiveness to antifungal therapy. The team identified metabolic pathways that shift during host invasion and presented metabolic vulnerabilities that can be exploited therapeutically. The study, summarized on BioTecNika, reframes antifungal strategies toward targeting fungal metabolism rather than only cell walls or membranes. Drug developers and antifungal research groups may prioritize metabolic enzyme inhibitors and metabolic-state diagnostics to improve treatment of invasive mycoses.