Studies have illuminated new links in cardiovascular pathology and genetics. Cardiac-specific overexpression of PRMT5 exacerbates heart failure caused by pressure overload, identifying a potential therapeutic target. The systemic immune-inflammation index shows prognostic value in heart failure with preserved ejection fraction. Research identifies sex-dependent differences in loss of A1BG gene correlating with cardiomyopathy phenotypes. Mendelian randomization methods have advanced causal understanding of ischemic stroke risk factors, potentially guiding future prevention strategies.