Lead: Researchers disclosed a next‑generation CAR‑T engineering approach that programs T cells to sense and exploit tumor-specific features rather than relying solely on single-antigen recognition. The study describes modular CAR constructs that integrate microenvironmental cues to improve tumor selectivity and persistence. Investigators reported preclinical data showing enhanced tumor killing while limiting off-tumor activity, citing assays of heterogeneous tumor models and microenvironment simulations. The team emphasized mechanistic readouts—cytokine profiles, exhaustion markers, and durability of memory phenotypes—to support translation. Authors proposed this design as a path to mitigate antigen escape and toxicity; the work sets the stage for IND-enabling work and suggests new biomarker strategies for early-phase trials.