Studies unravel mechanisms of resistance to therapies and immune modulation in cancer. UT Health San Antonio received $3.4M CPRIT funding to combat drug-resistant cancers using CRISPR and degrader platforms. VIB-KU Leuven discovered a paradoxical role of natural killer cells inhibiting CD8 T cell tumor infiltration in melanoma immune checkpoint resistance. Memorial Sloan Kettering uncovered metabolic regulation of intestinal stem cells linked to inflammation and cancer risk. Agenus collaborates with AI startup Noetik to model tumor microenvironments for improved immuno-oncology biomarker prediction.