Memorial Sloan Kettering Cancer Center presented multiple groundbreaking radiation therapy studies at the 2025 ASTRO meeting, highlighting novel approaches to improve treatment efficacy across cancers. Separately, Genialis partnered with Cleveland Clinic to develop AI-assisted biomarkers for pancreatic ductal adenocarcinoma, aiming to enhance therapy response prediction using RNA sequencing and organoid models. A new dynamic nomogram has been introduced to forecast brain metastasis risk in stage III non-small cell lung cancer patients undergoing chemoradiotherapy, offering improved personalized treatment planning. Collectively, these advances represent pivotal steps toward precision oncology and enhancing patient outcomes.