Cutting-edge studies elucidate critical aspects of cancer metabolism and microenvironment interactions. Disruption of lipid and phospholipid metabolism in Parkinson’s brains parallels tumor metabolism research, where fatty acid synthesis inhibition via natural compounds suppresses tumor growth. Mechanisms by which tumor-associated macrophages promote breast cancer metastasis via lncRNAs are unveiled. Additional findings highlight mitochondrial involvement in hormone receptor-positive breast cancer suppression and novel tumor targeting strategies preserving extracellular matrix integrity, offering multifaceted insights for therapeutic development targeting cancer progression and metastasis.