UCLA researchers uncovered that Insulin-like Growth Factor 2 mRNA-Binding Protein 3 (IGF2BP3) orchestrates both metabolic reprogramming and RNA methylation to promote leukemia cell proliferation. This protein acts as a master regulator redirecting glycolytic flux towards one-carbon metabolism and enhancing RNA modifications that support malignant growth. The findings reveal a critical dual role of IGF2BP3 in cancer biology, suggesting novel therapeutic targets that disrupt energy supply and survival signaling in leukemia cells.