Georgetown Lombardi Comprehensive Cancer Center researchers identified RAGE as a mechanistic link between aging and worse breast cancer metastatic behavior. In mouse models and analyses of human breast cancer samples, the team reported that RAGE activity increases with aging and metastatic progression. The findings, published in Communications Biology, suggest that aging-driven changes to the host inflammatory state amplify metastasis in a RAGE-dependent manner. The study also highlighted a gap in prior preclinical work: many experiments use younger mice, limiting insight into how aging itself reshapes tumor biology. The authors concluded that RAGE inhibition may represent a well-tolerated adjunctive therapeutic approach for older patients with breast cancer, with further work needed to validate translation to clinical settings.