Broad Clinical Labs, in collaboration with Roche and Boston Children’s Hospital, reported an ultra‑rapid whole‑genome sequencing protocol that reduces sample‑to‑variant turnaround to under four hours using Roche’s Sequencing‑by‑Expansion (SBX) platform. The team published the workflow in the New England Journal of Medicine and demonstrated its utility on neonatal ICU samples and reference genomes. Investigators say the speed could enable same‑day genomic diagnostics for critically ill infants, but note practical hurdles remain: device commercial readiness, throughput, cost and broader validation for routine clinical deployment. Roche’s SBX remains early access and not yet widely available.