Bristol Myers Squibb announced the appointment of Cristian Massacesi, former chief medical officer at AstraZeneca and its Alexion unit, as its new chief medical officer starting August 1. Massacesi will replace Samit Hirawat. His extensive oncology and rare disease development experience, including in radiopharmaceuticals and antibody-drug conjugates, positions him to steer BMS’s pipeline amid looming patent expirations and increased generic competition. The transition represents a strategic leadership refresh ahead of major product lifecycle challenges.