Scientists at the Arc Institute introduced an innovative gene-editing platform utilizing bridge recombinases, naturally occurring RNA-guided DNA-modifying enzymes, to rearrange large genomic segments in human cells. Demonstrating up to 20% efficiency for megabase-sized DNA insertions, deletions, or inversions, this method transcends conventional small-scale edits, offering transformative potential for gene therapies and genomic science by enabling complex genomic restructuring at unprecedented scale.