Researchers at the Arc Institute have engineered a novel, RNA-guided bridge recombinase platform that enables programmable large-scale genomic DNA rearrangements, including insertions, deletions, and inversions spanning up to a million base pairs. This breakthrough surpasses traditional gene editing that fixes small mutations, potentially revolutionizing gene therapy by allowing complex genome reengineering at scales comparable to evolutionary processes. The technology introduces versatile tools for manipulating human DNA with high efficiency and precision.