Researchers at the Arc Institute have developed novel bridge recombinases that enable unprecedented genome engineering by performing massive, programmable DNA rearrangements spanning hundreds of kilobases to megabases. This RNA-guided system allows cutting, pasting, inversion, and complex chromosomal reorganization within human cells at efficiencies up to 20%, vastly expanding capabilities beyond traditional gene editing tools. Such advances open avenues for sophisticated genetic therapies and research by modifying entire genomic regions at scale.