Significant advancements in organ transplantation are emerging with the integration of new technologies and methodologies. Normothermic regional perfusion (NRP) is revolutionizing liver transplantation by improving organ viability post-circulatory death. Single-cell sequencing and spatial transcriptomics are enhancing the understanding of kidney transplant biology, aiding personalized approaches. Studies also focus on optimizing donor-recipient genomic matching to increase transplant success rates and standardizing the interpretation of pre-transplant kidney biopsies.