Neuroscience research is rapidly advancing through innovative methodologies and technologies. Novel imaging techniques allow for detailed visualization of Parkinson’s disease motor symptom progression using non-negative matrix factorization. AI-driven digital monitoring provides new insights into mood instability in bipolar disorder. Transparency of mouse scalps has been achieved to facilitate real-time imaging of brain development. Additionally, chemogenetics offers promising interventions for addiction by rewiring neural circuits, heralding a new era in neurological treatment.