Scientists at King's College London developed a cutting-edge nanoneedle patch featuring tens of millions of microscopic silicon-based needles. This technology is poised to revolutionize diagnostics by enabling minimally invasive, painless molecular sampling directly from living tissues such as tumors or neurodegenerative regions. The patch allows for real-time monitoring, repeated tests on the same site, and spatiotemporal lipidomics, providing unprecedented insights into disease progression and therapeutic response with high molecular resolution. The innovation promises significant advances in personalized medicine and patient comfort.