Prominent studies have unveiled critical basic science advances that will impact biotech and therapeutic research. Notably, investigations into ribosome biogenesis reveal its m6A-mediated regulation essential to neural stem cell proliferation in brain development (Science Advances). Another landmark discovery decodes the molecular consequences of aneuploidy on mitochondrial precursor aggregation, linking chromosomal abnormalities to proteotoxic stress and mitochondrial dysfunction (Nature Communications). Additionally, research on the epilepsy-linked citrate transporter SLC13A5 delineates variant impacts via deep mutational scanning, illuminating mechanisms behind severe neurological disease (Science Advances). These foundational insights refine molecular targets and pathways relevant for clinical innovations.