Researchers from the University of Illinois Urbana-Champaign unveiled oPool+ display, a revolutionary high-throughput platform that integrates oligo pool synthesis with mRNA display to rapidly generate and functionally characterize hundreds of antibodies in parallel. Demonstrating its utility, the system profiled over 300 rare influenza hemagglutinin-specific antibodies across multiple viral variants through thousands of simultaneous binding assays within days. This technology dramatically cuts the time and cost of antibody discovery and characterization, addressing a longstanding bottleneck in therapeutic antibody development and enabling accelerated responses to emerging infectious diseases and complex biomedical challenges.