A comprehensive meta-analysis published in Journal for Immunotherapy of Cancer demonstrates vaccination therapies' potential to improve outcomes in glioblastoma multiforme (GBM), an aggressive brain tumor with poor prognosis. Studies reveal that vaccination strategies activate anti-tumor immunity and can induce apoptosis of GBM cells, potentially transforming therapeutic approaches. Researchers highlight promising advances in IL-24S/IL-15 fusion ‘superkine’ constructs and oncolytic viral vaccines expressing IL-12 as new avenues under investigation.