Recent research is unlocking complex genomic and molecular landscapes across diseases. New chromosome-level genome assemblies of vulnerable species like the Sichuan taimen provide key conservation insights. Studies reveal nicotine exposure during pregnancy affects colon Notch gene expressions, influencing development. Cutting-edge machine learning approaches improve Wilson disease prognosis by predicting acute-on-chronic liver failure, while systematic reviews assess leukemia predictive models. These advancements deepen molecular understanding and diagnostic potential for personalized medicine.