Researchers in China have developed Programmable Chromosome Engineering (PCE) systems enabling megabase-scale genomic edits with enhanced accuracy, overcoming key limitations of the Cre-Lox recombinase system. This includes novel asymmetric Lox sites, engineered Cre variants, and scarless editing strategies. In parallel, advances in computational biology have facilitated the design of artificial proteins, including binders for intrinsically disordered proteins, using AI-powered diffusion modeling and deep learning tools—expanding therapeutic and research possibilities in targeting challenging proteins.