Recent research breakthroughs deepen understanding of gene regulation and chromatin dynamics impacting various diseases. German scientists developed a buffer modification enabling CUT&Tag assays to map transcription factor binding effectively, enhancing epigenomic profiling capabilities. Studies on epigenetic regulation in thyroid cancer and molecular mechanisms such as PRMT1 in corneal epithelial homeostasis provide insights into gene expression control relevant for cancer and tissue regeneration. Additionally, novel CRISPR chemical tagging techniques offer safer gene editing avenues for genetic disease therapy.