Dr. David Ezra Gordon’s lab at Emory University presented pioneering use of trapped ion mobility mass spectrometry to create a comprehensive proteomic and phosphoproteomic atlas of in vivo exhausted antigen-specific CD8⁺ T cells. This approach uncovered protein-level features missed by transcriptomics, providing new insights into T-cell exhaustion mechanisms relevant to cancer immunotherapy. The work, conducted with collaborators using the LCMV mouse model, advances understanding of immune checkpoint blockade responses and potential therapeutic targets.