Researchers have constructed the largest genetic map linking human genetics and metabolism by analyzing data from approximately 450,000 individuals via the UK Biobank. Employing nuclear magnetic resonance spectroscopy, they identified associations across nearly 30,000 locus-metabolite pairs within 753 genomic regions, spanning small molecules and lipoprotein traits across multiple ancestries and sexes. The study provides insights into genes influencing metabolism, some previously unrecognized, and their roles in disease predisposition. This extensive resource offers a valuable blueprint to understand metabolic variability and potential therapeutic targets.