At the 41st Annual Meeting of the European Society of Human Reproduction and Embryology, investigators revealed associations between altered gut microbiota and amino acid metabolism with increased miscarriage risk in women with polycystic ovary syndrome (PCOS). The findings implicate premature biological aging linked to microbiome and metabolic dysregulation as potential contributors to reproductive failures. This research underscores the importance of gut health in PCOS management and fertility prognosis.