Scientists at the University of California developed ClearSeqExtend, an advanced computational platform improving single-cell RNA sequencing analysis by correcting ambient RNA contamination and batch effects. This tool enhances data quality and enables integrated multi-omics and cell-cell communication analyses, aiding research in neurodegeneration and cancer. Complementary innovations in tools like SCOPE allow researchers to identify protein-DNA interactions governing gene expression, revolutionizing the study of cellular heterogeneity and regulatory networks in health and disease.