Researchers at EPFL have introduced BindCraft, a novel AI-powered pipeline for designing highly specific protein binders targeting challenging biomolecular interfaces. Achieving success rates between 10% and 100% without high-throughput experimental screening, BindCraft can generate multiple high-affinity binders from small libraries in a ‘one-shot’ fashion. Demonstrated on therapeutically relevant targets including cell-surface receptors and CRISPR-Cas9, this tool represents a significant advance in in silico protein engineering and therapeutic discovery.