Researchers at the Institute for Bioengineering of Catalonia, in collaboration with Dexeus University Hospital, have successfully recorded, for the first time, the three-dimensional real-time implantation process of human embryos. Utilizing synthetic uterine platforms mimicking the extracellular matrix and mechanical environment, the team captured detailed biomechanical interactions between embryos and their surroundings over six days of development. This landmark achievement provides novel insights into the critical bottleneck of human reproduction and may inform future fertility and pregnancy loss interventions.