A team led by Professor Hiroaki Suzuki at Chuo University has developed a microfluidic-based method to mass-produce uniform artificial lipid bilayer vesicles containing DNA condensates serving as model eukaryotic nuclei. This innovative approach utilizes osmotic pressure to induce DNA nanostar condensation inside giant unilamellar vesicles with high reproducibility and structural control. The system also supports in-vesicle protein synthesis from these artificial nuclei, marking a significant advance in bottom-up synthetic biology and the creation of functional synthetic cells. The work was published in the journal JACS Au.