Scientists at Scripps Research have identified dozens of human host proteins critical to the replication and late stages of SARS-CoV-2 infection through an extensive genome-wide siRNA screening. This discovery highlights pathways like Wnt signaling and MAPK signaling as vital to viral propagation. Targeting host factors presents an innovative therapeutic strategy offering resilience against viral mutations. The findings outline potential pan-coronavirus drug targets, advancing antiviral drug development amidst the ongoing pandemic.