Researchers at Children’s Mercy Kansas City published data demonstrating that clinical long-read whole-genome sequencing (WGS) increases diagnostic yield to 37% compared to 27% for conventional methods, while significantly reducing time to diagnosis. The study highlights key capabilities unique to long-read technology, including detection of rare repeat expansions and structural variants. This positions long-read WGS as a potential single-test solution for complex genetic disorders, despite challenges related to cost and data analysis.