Scientists from Cincinnati Children’s Hospital Medical Center have engineered liver organoids capable of forming their own specialized blood vessel networks resembling human liver vasculature. Utilizing a multilayered gel matrix process, they successfully coaxed sinusoidal endothelial cells to migrate and establish functional vascular structures integral to tissue viability. This advance enhances organoid physiological relevance and paves the way for more accurate disease modeling and future regenerative therapies for liver conditions such as hemophilia and liver failure.