Scientists at the University of British Columbia have successfully conducted the first human transplant of a kidney enzymatically converted from blood type A to universal type O. The enzyme treatment removes blood group antigens, mitigating hyperacute rejection risk. The kidney functioned without severe rejection signs for two days post-transplant in a deceased donor model, ushering a transformative approach that could alleviate organ shortage and expand transplantation compatibility. Published in Nature Biomedical Engineering, this decade-long effort signals significant advancement in immunologically compatible organ transplantation.