Researchers at Chuo University, led by Professor Hiroaki Suzuki, have developed a cutting-edge method for mass-producing artificial cells containing model nuclei using microfluidic technology. The technique generates uniform giant unilamellar vesicles embedding DNA condensates that mimic natural chromatin organization. By carefully controlling vesicle volume through osmotic pressure, the method triggers DNA nanostar assembly without damaging sensitive macromolecules, enabling protein synthesis from within these synthetic compartments. This advances synthetic biology by facilitating bottom-up construction of complex cell-like systems with hierarchical genomic structures, potentially revolutionizing biomimetic applications and drug discovery.