A team at the University of Washington developed a novel protein on/off switch leveraging AI-guided design to facilitate rapid dissociation kinetics, accelerating cytokine signaling modulation by up to 6,000-fold. This strategy enables enhanced temporal control of protein interactions within cells, improving safety profiles for therapeutics like interleukin-2 and enabling precise activation or deactivation of biological signaling. Published in Nature, this work exemplifies advanced protein engineering for safer medicines and sensitive biosensors.