Researchers report transformative technologies in molecular biosciences. The S²ALM AI antibody language model revolutionizes antibody engineering. Methods that integrate single-cell proteomics with transcriptomics reveal complex gene expression dynamics during hematopoiesis. New experimental approaches decode partial molecular charges and elucidate epigenetic noise mechanisms impacting cellular identity. CRISPR-based in vivo neuronal gene screening advances functional genomics. DNA repair and protein evolution innovations expand therapeutic possibilities. Additionally, a new microhaplotype panel enhances forensic human identification capabilities.