A multidisciplinary team published detailed biophysical analyses linking lipid nanoparticle (LNP) architecture to delivery performance, illustrating that particle shape and internal structure correlate with payload release and tissue targeting. The studies, published in Nature Biotechnology and reported by university teams, used orthogonal techniques to visualize intact LNPs and associate structural motifs with biological outcomes. Investigators said the data provide practical guidance for tailoring LNPs to specific RNA therapies, moving formulation design beyond trial‑and‑error.