A new review in Medical Oncology summarizes emerging biology around disulfidptosis, a form of cancer cell death described as atypical compared with classical pathways. The article outlines proposed mechanistic contributors and highlights therapeutic targets under investigation. While still an evolving area, the review emphasizes disulfidptosis as a potential selectivity route—aiming to destroy tumor cells while sparing healthy tissue—an approach that continues to attract interest for next-generation oncology modalities.