Researchers developed a biomimetic mRNA delivery system that restores PTEN expression in colorectal tumors and enhances targeted immunotherapy activity. The platform delivers PTEN mRNA to tumor cells, reinstating tumor suppressor function and modulating the tumor microenvironment to improve immune engagement. Preclinical data indicate tumor control when combined with immunotherapeutic modalities; authors position the system as an option to address loss‑of‑function tumor suppressors with mRNA therapeutics, pending further delivery, safety and efficacy studies in clinical models.