A review argues electrical signals can improve bioprocess control by detecting early signs of culture failure faster than conventional assays in biologics manufacturing. It highlights advances in label-free approaches such as membrane capacitance, cytoplasmic conductivity, and dielectrophoresis signatures—potentially turning electrical properties into a real-time health timeline. The article underscores how CHO-cell studies link electrical phase changes to apoptosis progression, with membrane remodeling appearing before a sharp decline in cytoplasmic conductivity. It also notes early capture systems capable of measuring large cell populations quickly. For development and GMP operations, the practical implication is a new direction for real-time monitoring that could reduce batch loss and improve harvest timing—an area that remains a bottleneck for many manufacturers.