A Nature 2025 study introduces a soft, submicrometer-thick mesh microelectrode array that integrates with embryonic neural plates by leveraging natural brain morphogenesis from two-dimensional neural plates to three-dimensional structures. The device deforms with brain development, enabling long-term, stable recording of single-neuron to population dynamics without impairing brain function, demonstrated in axolotl models. This technology holds promise for advancing understanding of neurodevelopment and regeneration by providing comprehensive, minimally invasive neurophysiological mapping.