A Nature Communications team reported a bio‑adaptive physical hydrogel designed for dynamic tracheal reconstruction that interfaces mechanically with native tissue and supports epithelial regeneration. The hydrogel’s adaptive properties addressed long‑standing challenges in tracheal grafts, including compliance mismatch and dynamic airway motion. The material showed promising in vivo integration and functional airway support in preclinical models, positioning it as a candidate for translational development in tracheal surgery. Biomaterials firms and surgical device divisions will monitor scale‑up, long‑term remodeling outcomes and regulatory pathways for implantable tissue‑engineering products.