Researchers at EPFL unveiled BindCraft, an automated AI-driven pipeline achieving unprecedented 10-100% success rates designing functional protein binders in a single iteration. BindCraft targets traditionally undruggable interfaces, including nucleic acid-guided nucleases like CRISPR-Cas9, and demonstrates broad generalizability to novel protein folds. This innovation streamlines protein engineering by circumventing labor-intensive experimental screenings, promising transformative impacts on therapeutic development. Published in Nature, the pipeline offers robust affinity and functional activity suitable for diverse biomedical applications.